Opening for Pearl Jam (2006)

In 2006 Pear Jam invited My Morning Jacket to open for them on dates in Europe and the States.
"I was telling the guy how much they reminded me of the Band, whose music was a big influence on me. And as we were talking through the wall - I thought I was dreaming, but they were playing the Bands It Makes No Difference. So I looked at the cat and said 'Okay, interview over' and ran out and watched them play it."

- Eddie Vedder, about being interviewed backstage during one of My Morning Jacket's first sound checks
(Spin interview, May 2008)

Vedder sand the song with MMJ almost every night thereafter.